题组负责人
周芳芳博士 特聘教授 博导
周芳芳教授，2008年毕业于清华大学生物科学与技术系并获博士学位。2008-2013年在荷兰莱顿大学医学中心先后任职博士后、研究员。2013-2014年在荷兰莱顿大学医学中心任研究助理教授。2014年10月受聘千亿手机app下载生物医学研究院特聘教授及博士生导师。周芳芳教授长期致力于固有免疫分子机制以及肿瘤转移分子机制的研究，取得了多项科研成果。独立开展工作以后以通讯作者（含共同）在国际著名期刊如Nature Immunology（两篇）、Nature Cell Biology、Molecular Cell（两篇）、Nature Communications、Trends in Biochemical Sciences、Advanced Science、Signal Transduction and Targeted Therapy、Cell Death & Differentiation、Protein Cell、Cancer Research、Cell & Molecular Immunology、Frontiers in Immunology、Advanced Biosystems和Cancer letters等发表论文20篇。目前，周芳芳教授及其团队致力于肿瘤与免疫的互作及分子机制的研究。
主要研究方向:
1. 固有免疫的分子机制和生理、病理调控；
2. 肿瘤细胞转移过程中逃脱免疫监视的分子机制；
代表性论文（*Corresponding author; #Co-first authors）:
1. Zhang Z, Fang X, Wu X, Chu F, Ling L, Li J, Wang S, Zang J, Zhang B, Ye S, Zhang L, Yang B, Lin S, Huang H, Wang A, Zhou F*. Acetylation-dependent deubiquitinase OTUD3 controls MAVS activation in innate antiviral immunity. Molecular Cell. 2020
2. Dong Y, Dai T, Zhang L, Zhou F*. Coronavirus in continuous flux: from SARS-CoV to SARS-CoV-2. Advanced Science. 2020
3. Jin K, Zhang L, Zhou F*. An Effective Platform for Cancer Immunotherapy: Pooled Knockin Targeting for Genome Engineering Immunotherapies. Signal Transduction and Targeted Therapy. 2020
4. Cheng Z, Dai T, He X, Zhang Z, Xie F, Wang S, Zhang L, Zhou F*. The interaction between cGAS-STING pathway and pathogens. Signal Transduction and Targeted Therapy. 2020
5. Zhou X, Xie F, Wang L, Zhang L, Zhang S, Fang M, Zhou F*. The function and clinical application of extracellular vesicles in innate immune regulation. Cell Mol Immunol. 2020
6. Zhou L, Zhang Y, Wang Y, Zhang M, Sun W, Dai T, Wang A, Wu X, Zhang S, Wang S, Zhou F*. A dual role of type I interferons in antitumor immunity. Advanced Biosystems. 2020.
7. Wang S*, Zhou L, Ling L, Meng X, Chu F, Zhang S, Zhou F*. The Crosstalk Between Hippo-YAP Pathway and innate Immunity. Front Immunol. 2020
8. Cao J, Zhang M, Xie F, Lou J, Zhou X, Zhang L, Fang M, Zhou F*. Exosomes in Head and Neck Cancer: Roles, Mechanisms and Applications. Cancer Letters. 2020
9. Xie F, Zhou XX, Fang MY, Li HY, Su P, Tu YF, Zhang L, Zhou F*. Extracellular Vesicles in Cancer Immune Microenvironment and Cancer Immunotherapy. Advanced Science. 2019
10. Gao L, Wang L, Dai T, Jin K, Zhang Z, Wang S, Xie F, Fang P, Yang B, Huang H, van Dam H, Zhou F*, Zhang L*. Tumor-derived exosomes antagonize innate antiviral immunity. Nature Immunology. 2018
11. Wang S, Xie F, Chu F, Zhang Z, Yang B, Dai T, Gao L, Wang L, Ling L, Jia J, van Dam H, Jin J, Zhang L*, Zhou F*. YAP antagonizes innate antiviral immunity and is targeted for lysosomal degradation through kinase-IKKe mediated phosphorylation. Nature Immunology. 2017
12. Xie F, Jin K, Shao L, Fan Y, Tu YF, Yang B, van Dam H, Ten Dijke P, Weng HL, Dooley S, Wang S, Jia JL, Jin J, Zhou F*, Zhang L*. FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis. Nature Communications. 2017
13. Zhou F#, Xie F#, Jin K, Zhang ZK, Clerici M, Gao R, Sixma TK, Huang HZ, van Dinther M, Zhang L, Ten Dijke P. USP4 inhibits SMAD4 monoubiquitination and promotes activin and BMP signaling. EMBO Journal.2017
14. Zhang L*, Xie F, Ten Dijke P, Zhang J, Zhou F*. SUMO-triggered ubiquitination of NR4A1 controls macrophage cell death. Cell Death Differ.2017
15. Jin K*, Li T, van Dam H, Zhou F*, Zhang L*. Molecular insight into tumor metastasis: tracing the dominant events.J Pathol. 2016
16. Li Y, Jin K, van Pelt GW, van Dam H, Yu X, Mesker WE, Ten Dijke P, Zhou F*, Zhang L*. c-Myb Enhances Breast Cancer Invasion and Metastasis through the Wnt/beta-Catenin/Axin2 Pathway. Cancer Research. 2016
17. Zhou F#, Li F#, Fang P, Dai T, Yang B, van Dam H, Jia J, Zheng M, Zhang L. Ubiquitin-Specific Protease 4 Antagonize Osteoblast Differentiation through Dishevelled. J Bone Miner Res. 2016
18. Zhang J, Zhang X, Xie F, Zhang Z, van Dam H, Zhang L*, Zhou F*. The regulation of TGF-β/SMAD signaling by protein deubiquitination. Protein Cell. 2014
19. Zhou F, Drabsch Y, Dekker T.J.A, Vinuesa A.G.d, Li Y,Hawinkels L.J, Lu CX, Zhang L, Ten Dijke P. (2014) Nuclearreceptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-β signalling. Nature Communications. 2014
20. Zhang L*,Zhou F*, ten Dijke P*. (2013) Signaling interplay between transforming growthfactor-β receptor and PI3K/AKT pathways in cancer. Trends in Biochemical Sciences. 2013
21. Zhang L#,Zhou F#*, García de Vinuesa A, de Kruijf EM, Mesker WE, HuiL, Drabsch Y, Li Y, Bauer A, Rousseau A, Sheppard KA, Mickanin C, Kuppen PJ, LuCX, Ten Dijke P*. TRAF4 promotes TGF-β receptor signaling and drives breast cancer metastasis. Molecular Cell. 2013
22. Zhou F, Zhang XF, van Dam H, ten Dijke P, Huang HZ, Zhang L. Ubiquitin-specificprotease 4 mitigates Toll-like/Interleukin-1 receptor signaling and regulatesinnate immune activation. J Biol Chem. 2012
23. Zhang L#, Huang H#, Zhou F#, Pardo CG, Zhang T, Barakat TS, Sheppard KA, van Dam H, Gribnau J, Lu C, and ten Dijke P. RNF12 controls embryonic stem cell fate and morphogenesis in zebrafish embryos by targeting Smad7 for degradation. Molecular Cell. 2012
24. Zhang L#, Zhou F#*, Drabsch Y, Snaar-Jagalska E, Mickanin C, Huang H, Sheppard KA, Lu C,and ten Dijke P*. (2012) USP4is regulated by Akt phosphorylation and directly deubiquitinates TGF-β type Ireceptor. Nature Cell Biology. 2012
25. Zhang L#,Zhou F#*, van Laar T, Zhang J, van Dam H, ten Dijke P*. Fas-associated factor 1 antagonizes Wnt signaling by promoting β-catenin degradation. Mol Biol Cell. 2011
26. Zhou F#, Zhang L#, van Laar T, van Dam H, ten Dijke P. GSK3β inactivation induces apoptosis of leukemia cells by repressing the function of c-Myb. Mol Biol Cell. 2011
27. Zhou F#, Zhang L#, Wang A, Song B, Gong K, Zhang L, Hu M, Zhang X, Zhao N, Gong. The association of GSKβwith E2F1 facilitates nerve growth factor-induced neural cell differentiation. J Biol Chem. 2008
E-mail: zhoufangfang@guntechinc.com
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课题组成员
王帅 副研究员 硕导
王帅博士于2010年获得山东大学生物化学与分子生物学博士学位。2010年加中国科学院武汉病毒研究所担任助理研究员职位。2013年加入千亿手机app下载生物医学研究院，目前担任周芳芳课题组副研究员职位。
谢枫 师资博士后
谢枫于2017年3月获浙江大学细胞生物学专业博士学位，同年成为周芳芳教授课题组博士后，并获得国家“博新计划”资助。
张正奎统招博士后
张正奎于2018年6月获浙江大学细胞生物学专业博士学位，同年成为周芳芳教授课题组博士后，并获得国家“博新计划”资助。
褚峰 助理研究员
褚峰于2014年获得千亿手机app下载发育生物学专业硕士学位，同年加入千亿手机app下载周芳芳教授课题组担任技术员职位。
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